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Biochem Mol Biol Int. 1996 Apr;38(5):1013-22.

Oxidative phosphorylation and F(O)F(1) ATP synthase activity of human hepatocellular carcinoma.

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  • 1Institute of Medical Biochemistry and Chemistry, University of Bari, Italy.


A study of mitochondrial oxidative phosphorylation in biopsies from human hepatocellular carcinoma is presented. Tumour mitochondria as compared to control liver mitochondria, besides a reduced activity of complex IV (cytochrome c oxidase) of the respiratory chain, show a decreased phosphorylative capacity. This appears to be mainly related to a defective F o F(1) ATP synthase complex. Use of an antibody against the F(1) portion of the complex demonstrate a definite decrease for the beta subunit of F(1) in tumour mitochondria.

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