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The glycine receptor.
School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia.
The inhibitory glycine receptor (GlyR) is a member of the ligand-gated ion channel receptor superfamily. The GlyR comprises a pentameric complex that forms a chloride-selective transmembrane channel, which is predominantly expressed in the spinal cord and brain stem. We review the pharmacological and physiological properties of the GlyR and relate this information to more recent insights that have been obtained through the cloning and recombinant expression of the GlyR subunits. We also discuss insights into our understanding of GlyR structure and function that have been obtained by the genetic characterisation of various heritable disorders of glycinergic neurotransmission.
PMID: 9131721 [PubMed - indexed for MEDLINE]
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Cited by 13 PubMed Central articles
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Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation.
Lobo IA, Harris RA, Trudell JR.
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[J Neurochem. 2008]
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The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats.
Bunaciu RP, Tharappel JC, Lehmler HJ, Kania-Korwel I, Robertson LW, Srinivasan C, Spear BT, Glauert HP.
Toxicology. 2007 Oct 8; 239(3):147-55. Epub 2007 Jul 7.
[Toxicology. 2007]
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ReviewTandem couture: Cys-loop receptor concatamer insights and caveats.
Ericksen SS, Boileau AJ.
Mol Neurobiol. 2007 Feb; 35(1):113-28.
[Mol Neurobiol. 2007]
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