Clin Pharmacol Ther. 1977 Nov;22(5 Pt 1):550-6.

Tolerance to marijuana: heart rate and subjective "high".

Abstract

In a 94-day supervised study of 30 subjects smoking marijuana, with drug-free periods interspersed, mean heart rate and subjective "high" decreased over the smoking period. Light smokers had greater chronotrophic and subjective effects than heavy smokers, but both demonstrated evidence of tolerance. Cumulation and minor withdrawal effects were noted.

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Tetrahydrocannabinol

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