Send to:

Choose Destination
See comment in PubMed Commons below
Eur J Vasc Endovasc Surg. 1997 Mar;13(3):306-14.

A prospective study of the effect of limb-threatening ischaemia and its surgical treatment on the quality of life.

Author information

  • 1Department of Vascular Surgery, Royal Hallamshire Hospital, Sheffield, U.K.



To assess the quality of life after treatment for limb-threatening ischaemia.


An open, prospective, observational study in a Vascular Unit of a University Hospital.


One hundred and fifty consecutive patients presenting with actual or threatened tissue loss of the leg.


A single, experienced observer assessed the patients for pain, mobility, anxiety, depression, self-care and lifestyle at presentation, 6 and 12 months later.


Six different treatment outcomes were recognised: successful angioplasty, successful thrombolysis/thrombectomy, successful surgical bypass, amputation after failed revascularisation, primary unilateral amputation and primary bilateral amputation. Pain was significantly improved in all groups (p < 0.05) except for patients after failed revascularization (p = 0.08). Mobility improved in patients who underwent angioplasty (p = 0.05) or a successful surgical bypass (p = 0.001). Anxiety and depression both improved significantly only after surgical reconstruction (p < 0.02). Self-care ability improved significantly after angioplasty (p < 0.05), surgical reconstruction (p < 0.005) and unilateral primary amputation (p < 0.05), but was unaltered in the other groups. Lifestyle significantly deteriorated following thrombolysis/thrombectomy and failed surgical reconstruction (p < 0.05), but was maintained in all other groups.


The treatment of limb-threatening ischaemia should aim to maintain pre-morbid lifestyle, an aim which is best achieved by limb-salvage. The patient's own expectations and needs have a major bearing on the choice of therapy.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk