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    Biochim Biophys Acta. 1997 Apr 12;1360(2):97-101.

    Molecular cloning of murine ICA69: diabetes-prone mice recognize the human autoimmune-epitope, Tep69, conserved in splice variants from both species.

    Karges W, Gaedigk R, Hui MF, Cheung R, Dosch HM.

    Source

    The Hospital for Sick Children, University of Toronto, Department of Pediatrics, Ontario, Canada.

    Abstract

    The islet cell antigen ICA69 is an autoimmune target in most patients with insulin-dependent diabetes. Understanding its role in diabetic autoimmunity would be facilitated by an animal model. We therefore cloned mouse ICA69. The different splice variants now identified conserve Tep69, the single T cell epitope recognized by patient T cells. We show that diabetes-prone NOD mice had Tep69-specific, autoreactive T cell repertoires and thus provide a relevant model for the study of ICA69's role in diabetic autoimmunity.

    PMID:
    9128175
    [PubMed - indexed for MEDLINE]

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