Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neurosci Lett. 1997 Jan 17;221(2-3):181-4.

Motor neurons in human and rat spinal cord synthesize fibroblast growth factor-9.

Author information

  • 1Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Kamikitazawa, Setagaya, Japan. snakamu@prit.go.jp

Abstract

Fibroblast growth factor (FGF)-9, initially referred to as a glia-activating factor, is a recently identified member of the FGF family. In the present study we demonstrated that spinal cord motor neurons and dorsal root ganglion neurons were strongly immunostained with specific antibodies to FGF-9 in human and rat tissues. By in situ hybridization using digoxigenin-labeled antisense probe to FGF-9 mRNA, we found specific signals in these neurons in rat. By immunoblotting analysis, we detected a 30/29 kDa doublet band in human spinal cord proteins, which corresponded to the doublet band of originally isolated FGF-9 from culture media. Our results indicate that these neurons synthesize FGF-9.

PMID:
9121694
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk