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    FEBS Lett. 1997 Mar 10;404(2-3):135-9.

    Identification and characterization of homologues of the Exocyst component Sec10p.

    Guo W, Roth D, Gatti E, De Camilli P, Novick P.

    Source

    Yale University School of Medicine, Department of Cell Biology, New Haven, CT 06510, USA.

    Abstract

    The SEC10 gene product is a member of the Exocyst complex essential for exocytosis in the budding yeast Saccharomyces cerevisiae. We report here the cloning and characterization of human Sec10p (hSec10p; GenBank accession number U85946). hSec10p is a 77-kDa protein with 23% amino acid identity to yeast Sec10p and 37% identity to a C. elegans protein found in the database. Northern and Western blot analyses indicate that hSec10 has a broad tissue distribution. Immunofluorescence staining of COS cells cotransfected with hSec10p and a mammalian Sec8p demonstrates that these two proteins have an identical distribution in the cell including a localization in the peripheral cytoplasm. These data suggest that hSec10p is a component of the mammalian counterpart of the yeast Exocyst complex essential for post-Golgi traffic.

    PMID:
    9119050
    [PubMed - indexed for MEDLINE]

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