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    Genes Cells. 1997 Jan;2(1):13-28.

    The N-end rule pathway of protein degradation.

    Source

    Division of Biology, California Institute of Technology, Pasadena 91125, USA. varshavskya@starbase1.caltech.edu

    Abstract

    The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. Ubiquitin is a 76-residue protein whose covalent conjugation to other proteins plays a role in many biological processes, including cell growth and differentiation. I discuss the current understanding of the N-end rule pathway.

    PMID:
    9112437
    [PubMed - indexed for MEDLINE]

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