Format

Send to:

Choose Destination
See comment in PubMed Commons below
Gen Pharmacol. 1997 Jan;28(1):7-12.

Recent studies on dendrotoxins and potassium ion channels.

Author information

  • 1Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, UK.

Abstract

1. Dendrotoxins are small proteins isolated from mamba (Dendroaspis) snake venoms. They block some subtypes of voltage-dependent potassium channels in neurons. 2. Dendrotoxins contain 57-60 amino acid residues crosslinked by three disulfide bridges. They are homologous to Kunitz-type serine protease inhibitors, such as aprotinin, although they have little or no antiprotease activity. 3. Dendrotoxins act mainly on neuronal K+ channels. Studies with cloned K+ channels indicate that alpha-dendrotoxin from green mamba Dendroaspis angusticeps blocks Kv1.1 and Kv1.2 channels in the nanomolar range. In native cells, dendrotoxin appears preferentially to block inactivating forms of K+ current. 4. Dendrotoxins can induce repetitive firing in neurons and facilitate transmitter release. On direct injection to the CNS, dendrotoxins can induce epileptiform activity. 5. Radiolabeled dendrotoxins are useful markers of subtypes of K+ channels in vivo, and structural analogs help to define the molecular recognition properties of different types of K+ channels.

PMID:
9112070
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk