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Trends Microbiol. 1997 Feb;5(2):70-3.

Molecular mimicry between Helicobacter pylori and the host.

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  • 1Dept of Medical Microbiology, Vrije Universiteit, Amsterdam, The Netherlands.


Helicobacter pylori lipopolysaccharide (LPS) expresses Lewis x and Lewis y blood group antigens that are identical to those occurring in the human gastric mucosa. During infection, antibodies against LPS, which bind to host Lewis antigens, may be induced. These consequently recognize gastric glycoprotein targets and cause autoimmune inflammation.

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