J Autism Dev Disord. 1997 Apr;27(2):155-63.

CSF beta-endorphin levels in patients with infantile autism.

Nagamitsu S, Matsuishi T, Kisa T, Komori H, Miyazaki M, Hashimoto T, Yamashita Y, Ohtaki E, Kato H.

Source

Department of Pediatrics and Child Health, Kurume University School of Medicine, Japan.

Abstract

We measured CSF levels of beta-endorphin, an opioid hormone, in 19 patients with infantile autism and in 3 patients with Rett syndrome, and compared them with control values. In infantile autism, CSF levels of beta-endorphin did not differ significantly from those of age-matched controls. There was no significant correlation between CSF levels and clinical symptoms, including self-injurious behavior, pain insensitivity, and stereotyped movement. However, CSF levels of beta-endorphin were significantly higher in the patients with Rett syndrome than in the control (p < .05). Data suggest that neurons containing beta-endorphin may not be involved in patients with infantile autism. Thus, there is no relationship between dysfunction of brain opioid and autism.

PMID:: 9105966; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

beta-Endorphin

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

CSF beta-endorphin levels in pediatric neurologic disorders. [Kurume Med J. 1993]
CSF beta-endorphin levels in pediatric neurologic disorders.
Nagamitsu S. Kurume Med J. 1993; 40(4):233-41.
CSF beta-endorphins in childhood neuropsychiatric disorders. [Brain Dev. 1990]
CSF beta-endorphins in childhood neuropsychiatric disorders.
Gillberg C, Terenius L, Hagberg B, Witt-Engerström I, Eriksson I. Brain Dev. 1990; 12(1):88-92.
Difference between plasma N- and C-terminally directed beta-endorphin immunoreactivity in infantile autism. [Am J Psychiatry. 1994]
Difference between plasma N- and C-terminally directed beta-endorphin immunoreactivity in infantile autism.
Leboyer M, Bouvard MP, Recasens C, Philippe A, Guilloud-Bataille M, Bondoux D, Tabuteau F, Dugas M, Panksepp J, Launay JM. Am J Psychiatry. 1994 Dec; 151(12):1797-801.
Review [Rett syndrome. A report of fifteen cases]. [Ann Pediatr (Paris). 1989]
Review [Rett syndrome. A report of fifteen cases].
Echenne B, Bressot N, Cheminal R, Van Leuwen F, Compagnon P, Azaïs M. Ann Pediatr (Paris). 1989 Dec; 36(10):661-8.
Review Clinical neurochemistry of autism and associated disorders. [J Autism Dev Disord. 1982]
Review Clinical neurochemistry of autism and associated disorders.
Young JG, Kavanagh ME, Anderson GM, Shaywitz BA, Cohen DJ. J Autism Dev Disord. 1982 Jun; 12(2):147-65.

See reviews... See all...

Cited by 3 PubMed Central articles

Review [Autism and pain - a literature review]. [Pain Res Manag. 2010]
Review [Autism and pain - a literature review].
Dubois A, Rattaz C, Pry R, Baghdadli A. Pain Res Manag. 2010 Jul-Aug; 15(4):245-53.
Non-suicidal self-injurious behavior, endogenous opioids and monoamine neurotransmitters. [J Affect Disord. 2010]
Non-suicidal self-injurious behavior, endogenous opioids and monoamine neurotransmitters.
Stanley B, Sher L, Wilson S, Ekman R, Huang YY, Mann JJ. J Affect Disord. 2010 Jul; 124(1-2):134-40. Epub 2009 Nov 25.
Pain reactivity and plasma beta-endorphin in children and adolescents with autistic disorder. [PLoS One. 2009]
Pain reactivity and plasma beta-endorphin in children and adolescents with autistic disorder.
Tordjman S, Anderson GM, Botbol M, Brailly-Tabard S, Perez-Diaz F, Graignic R, Carlier M, Schmit G, Rolland AC, Bonnot O, et al. PLoS One. 2009 Aug 26; 4(8):e5289. Epub 2009 Aug 26.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

CSF beta-endorphin levels in patients with infantile autism.
CSF beta-endorphin levels in patients with infantile autism.
J Autism Dev Disord. 1997 Apr ;27(2):155-63.

PubMed
Enterobacter spp.: pathogens poised to flourish at the turn of the century.
Enterobacter spp.: pathogens poised to flourish at the turn of the century.
Clin Microbiol Rev. 1997 Apr ;10(2):220-41.

PubMed
Sequence, splice site and population frequency distribution analyses of the poly...
Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7.
Brain Res Mol Brain Res. 1997 Apr ;45(1):145-8.

PubMed
Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte a...
Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease.
Atherosclerosis. 1997 Mar 21 ;129(2):261-9.

PubMed
Effect of quercetin on Hoechst 33342 transport by purified and reconstituted P-g...
Effect of quercetin on Hoechst 33342 transport by purified and reconstituted P-glycoprotein.
Biochem Pharmacol. 1997 Feb 21 ;53(4):587-96.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: