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J Rheumatol. 1997 Apr;24(4):714-8.

Orthostatic sympathetic derangement in subjects with fibromyalgia.

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  • 1Instituto Nacional de Cardiolagía Ignacio Chávez, Hospital Gea Gonzalez, México DF, México.

Abstract

OBJECTIVE:

To assess the sympathetic-parasympathetic balance in individuals with fibromyalgia (FM), and its response to orthostatic stress, by power spectral analysis of heart rate variability.

METHODS:

We studied 19 women with FM and 19 age matched controls. A high resolution electrocardiogram was obtained in supine and standing postures after achieving a stable heart rate. Spectral analysis of R-R intervals was done by the fast Fourier transform algorithm.

RESULTS:

Analyses of the different frequency components revealed significant difference between the 2 groups in the low frequency (0.050-0.150 Hz) band, which reflects modulation of the sympathetic nervous system. Controls displayed an increased power spectral density upon standing (+0.081 +/- 0.217 Hz); individuals with FM had a discordant response (-0.057 +/- 0.097 Hz) (p = 0.018).

CONCLUSION:

In FM, there is a deranged sympathetic response to orthostatic stress. This abnormality may have implications regarding the pathogenesis of FM.

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PMID:
9101507
[PubMed - indexed for MEDLINE]
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