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Am J Public Health. 1997 Mar;87(3):443-5.

The effect of postmenopausal estrogen therapy on the risk of non-insulin-dependent diabetes mellitus.

Author information

  • 1Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093-0607, USA.

Abstract

OBJECTIVES:

This study examined the effect of postmenopausal estrogen replacement therapy on the incidence of non-insulin-dependent diabetes in women.

METHODS:

Postmenopausal women aged 50 through 70 years (n=848) without diagnosed diabetes at baseline were followed for 10 to 15 years for incident diabestes.

RESULTS:

Over the average 11.5 year follow-ip, there were 105 new cases of diabetes. The age-adjusted relative-risk for development of diabetes was nonsignificantly lower for women with continuous estrogen replacement therapy use than for never users. After adjustment for major covariates, a nonsignificant linear trend with increasing duration of estrogen replacement therapy was reversed.

CONCLUSIONS:

This study suggests that previous results showing a reduced risk of diabetes in women using estrogen may have been due to selection bias regarding who is prescribed estrogen, confounding factors, or differential diagnostic efforts.

PMID:
9096551
[PubMed - indexed for MEDLINE]
PMCID:
PMC1381022
Free PMC Article
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