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Curr Opin Struct Biol. 1997 Apr;7(2):247-57.

Architecture and function in the muscle sarcomere.

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  • Biophysics Section, Blackett Laboratory, Imperial College, London, SW7 2BZ, UK. j.squire@ic.ac.uk


Striated muscle sarcomeres in vertebrates comprise ordered arrays of actin and myosin filaments, organized by an elaborate protein scaffold. Recent innovative work in a number of laboratories has greatly improved our knowledge of these structures, their organization and their interactions. Structural details have been reported on myosin filaments, actin filaments, Z-bands, M-bands, titin, and nebulin. Time-resolved X-ray diffraction and electron microscopy are revealing the molecular movements involved in force production and regulation.

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