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Clin Genet. 1997 Jan;51(1):65-8.

Two mosaic-YY males carrying asymmetric Y chromosomes.

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  • 1Servizio di Genetica Medica, IRCCS, Ospedale CSS San Giovanni Rotondo, Italy.


Two patients were referred because of oligospermia and azospermia, respectively. Karyotypic analysis revealed two mosaic-YY males carrying asymmetric Y chromosomes. To our knowledge, no instance of double unequal Y chromosomes has been reported so far in human males. Results of fluorescent in situ hybridization (FISH) studies in spermatozoa from one of these patients revealed a significantly high number of hyperaploid spermatozoa.

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