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Science. 1997 Apr 4;276(5309):111-3.

The receptor for the cytotoxic ligand TRAIL.

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  • 1Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Abstract

TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. The human receptor for TRAIL was found to be an undescribed member of the TNF-receptor family (designated death receptor-4, DR4) that contains a cytoplasmic "death domain" capable of engaging the cell suicide apparatus but not the nuclear factor kappa B pathway in the system studied. Unlike Fas, TNFR-1, and DR3, DR4 could not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery. Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis.

PMID:
9082980
[PubMed - indexed for MEDLINE]
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