Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Immunol Today. 1997 Mar;18(3):140-5.

Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH.

Author information

  • 1Dept of Physiology, University of Texas Southwestern Medical Center at Dallas 75235-9040, USA. LIPTON@UTSW.SWMED.EDU

Abstract

alpha-melanocyte-stimulating hormone (alpha-MSH) is an endogenous neuroimmunomodulatory peptide that inhibits fever and all major forms of experimental inflammation. In humans, concentrations of alpha-MSH are increased at sites of inflammation, and in plasma in inflammatory disorders and after infection of endotoxin. The effects of this 'anti-cytokine' peptide are mediated through alpha-MSH receptors and regulatory circuits in macrophages and neutrophils, and through descending neural anti-inflammatory pathways that originate from alpha-MSH receptors on neurons within the brain.

PMID:
9078687
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk