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Annu Rev Physiol. 1997;59:457-82.

Chemical activators of sensory neurons.

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  • 1Department of Anatomy and Developmental Biology, University College, London, United Kingdom.


Chemical activation of sensory neurons plays an important role in the somatosensory system. The actions of both endogenous mediators such as excitatory amino acids, acetylcholine, bradykinin, and ATP, as well as selective exogenous activators of nociceptive sensory neurons are reviewed. The physiological significance of these mediators in both nociception and other types of sensation are discussed.

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