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Biochem Biophys Res Commun. 1997 Feb 13;231(2):509-13.

DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras.

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  • 1Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

Abstract

We have isolated and characterized the cDNA encoding a novel protein designated DJ-1. DJ-1, sharing no significant homology with the sequences so far reported, did not show transactivation activity in the Gal4 recombinant system, but transformed mouse NIH3T3 cells by itself. Furthermore, DJ-1 showed a cooperative transforming activity with H-Ras, more than 3 times as strong as the activity of ras/myc combination. DJ-1 was ubiquitously expressed in various human tissues, and the expression was induced by growth stimuli. Moreover, DJ-1 translocated from cytoplasm to nuclei in the S phase of the cell cycle. DJ-1 is thus suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway.

PMID:
9070310
[PubMed - indexed for MEDLINE]
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