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Curr Opin Cell Biol. 1997 Apr;9(2):168-73.

Lysophosphatidic acid: G-protein signalling and cellular responses.

Author information

  • 1Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 X Amsterdam, The Netherlands. wmoolen@nki.nl


Lysophosphatidic acid (LPA) is a serum-borne phospholipid that activates a specific G protein coupled receptor to evoke multiple cellular responses. Recent work has identified two cDNAs encoding putative LPA receptors, various LPA-like agonists that act on distinct receptors, and new pathways that link the receptor(s) to such diverse events as Ras signalling, cytoskeletal remodelling and membrane depolarization.

[PubMed - indexed for MEDLINE]
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