Lysophosphatidic acid: G-protein signalling and ce...[Curr Opin Cell Biol. 1997]

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1: Curr Opin Cell Biol. 1997 Apr;9(2):168-73. Links

Lysophosphatidic acid: G-protein signalling and cellular responses.

Moolenaar WH, Kranenburg O, Postma FR, Zondag GC.

Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 X Amsterdam, The Netherlands. wmoolen@nki.nl

Lysophosphatidic acid (LPA) is a serum-borne phospholipid that activates a specific G protein coupled receptor to evoke multiple cellular responses. Recent work has identified two cDNAs encoding putative LPA receptors, various LPA-like agonists that act on distinct receptors, and new pathways that link the receptor(s) to such diverse events as Ras signalling, cytoskeletal remodelling and membrane depolarization.

PMID: 9069262 [PubMed - indexed for MEDLINE]

ReviewBioactive lysophospholipids and their G protein-coupled receptors.
Exp Cell Res. 1999 Nov 25; 253(1):230-8.

[Exp Cell Res. 1999]
Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid.
J Biol Chem. 1999 Sep 24; 274(39):27776-85.

[J Biol Chem. 1999]
Exogenous phospholipase D generates lysophosphatidic acid and activates Ras, Rho and Ca2+ signaling pathways.
Curr Biol. 1998 Mar 26; 8(7):386-92.

[Curr Biol. 1998]
A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid.
Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6151-6.

[Proc Natl Acad Sci U S A. 1998]
ReviewSignaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate.
J Cell Biochem Suppl. 1998; 30-31:147-57.

[J Cell Biochem Suppl. 1998]
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