Curr Opin Cell Biol. 1997 Apr;9(2):174-9.

The complexity of Raf-1 regulation.

Source

Molecular Basis of Carcinogenesis Laboratory, ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.

Abstract

The activation of the serine/threonine kinase Raf-1 is proving to be an intricate multistep process. Recent advances in elucidating how Raf-1 becomes activated in response to signaling events have emphasized the role of phosphorylation and protein interactions in Raf-1 regulation. The picture clearly emerging is that Raf-1 activity can be regulated by multiple mechanisms.

PMID:: 9069260; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro. [EMBO J. 1997]
Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro.
Stokoe D, McCormick F. EMBO J. 1997 May 1; 16(9):2384-96.
Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors. [Mol Cell Biol. 2000]
Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors.
Lee AW, States DJ. Mol Cell Biol. 2000 Sep; 20(18):6779-98.
Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak. [Curr Biol. 2000]
Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak.
Sun H, King AJ, Diaz HB, Marshall MS. Curr Biol. 2000 Mar 9; 10(5):281-4.
Review Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. [Recent Prog Horm Res. 2001]
Review Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade.
Avruch J, Khokhlatchev A, Kyriakis JM, Luo Z, Tzivion G, Vavvas D, Zhang XF. Recent Prog Horm Res. 2001; 56:127-55.
Review Ras-Raf complexes: analyses of complexes formed in vivo. [Methods Enzymol. 1995]
Review Ras-Raf complexes: analyses of complexes formed in vivo.
Finney R, Herrera D. Methods Enzymol. 1995; 255:310-23.

See reviews... See all...

Cited by 95 PubMed Central articles

Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis. [Arthritis Res Ther. 2010]
Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis.
Charpin C, Martin M, Balandraud N, Roudier J, Auger I. Arthritis Res Ther. 2010; 12(5):R194. Epub 2010 Oct 18.
Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA. [Br J Pharmacol. 2010]
Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA.
Tumati S, Roeske WR, Largent-Milnes T, Wang R, Vanderah TW, Varga EV. Br J Pharmacol. 2010 Sep; 161(1):51-64.
Review Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response. [Clin Cancer Res. 2010]
Review Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response.
Pratilas CA, Solit DB. Clin Cancer Res. 2010 Jul 1; 16(13):3329-34. Epub 2010 May 14.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

The complexity of Raf-1 regulation.
The complexity of Raf-1 regulation.
Curr Opin Cell Biol. 1997 Apr ;9(2):174-9.

PubMed
Use of bacteriophage T7 RNA polymerase to direct selective high-level expression...
Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.
J Mol Biol. 1986 May 5 ;189(1):113-30.

PubMed
Ultrastructural and immunohistochemical characteristics of lipid-rich carcinoma ...
Ultrastructural and immunohistochemical characteristics of lipid-rich carcinoma of the breast.
Virchows Arch A Pathol Anat Histopathol. 1988 ;413(5):381-5.

PubMed
Treatment of hepatic encephalopathy with metronidazole.
Treatment of hepatic encephalopathy with metronidazole.
Gut. 1982 Jan ;23(1):1-7.

PubMed
Linking empirically based theory and evaluation: the Family Bereavement Program.
Linking empirically based theory and evaluation: the Family Bereavement Program.
Am J Community Psychol. 1992 Aug ;20(4):491-521.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: