Trends Biochem Sci. 1997 Mar;22(3):87-92.

Chaperones get in touch: the Hip-Hop connection.

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Department of Biological Sciences, Stanford University, CA 94305-5020, USA. jfrydman@leland.stanford.edu

Abstract

Recent findings emphasize that different molecular chaperones cooperate during intracellular protein biogenesis. Mechanistic aspects of chaperone cooperation are now emerging from studies on the regulation of certain signal transduction pathways mediated by Hsc70 and Hsp90 in the eukaryotic cytosol. Efficient cooperation appears to be achieved through a defined regulation of Hsc70 activity by the chaperone cofactors Hip and Hop.

PMID:: 9066258; [PubMed - indexed for MEDLINE]

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