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Semin Reprod Endocrinol. 1997 Feb;15(1):55-68.

Psychobiology of premenstrual dysphoric disorder.

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  • University of California, Department of Psychiatry, San Diego, La Jolla 92093, USA.


Premenstrual Dysphoric Disorder (PMDD) is the new terminology used in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). It more rigorously defines criteria for what historically has been referred to as premenstrual syndrome (PMS). Based on studies of its phenomenology and course, PMDD was categorized in DSM-IV as a depressive mood disorder. Findings support low serotonin and melatonin metabolism in PMDD compared with healthy control subjects, and an increasing number of rigorous studies report a reduction of symptoms with selective serotonin reuptake inhibitors (SSRIs).

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