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Vet Res Commun. 1997 Feb;21(2):127-36.

The plasma kinetics and tissue distribution of enrofloxacin and its metabolite ciprofloxacin in the Muscovy duck.

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  • 1Laboratory of Veterinary Pharmacology and Toxicology, University of Pisa, Italy.

Erratum in

  • Vet Res Commun 1997 May;21(4):240.

Abstract

The disposition and tissue distribution of enrofloxacin and of its main metabolite ciprofloxacin were investigated in ducks after oral or intramuscular administration of a single dose of 10 mg/kg enrofloxacin. Plasma and tissue concentrations were determined by a HPLC method. The peak concentrations of enrofloxacin after intramuscular administration (1.67 micrograms/ml at 0.9 h) were higher than after an oral dose (0.99 microgram/ml at 1.38 h). The relative bioavailability of enrofloxacin after administration directly into the crop was 68%, while the metabolic conversion of enrofloxacin to ciprofloxacin was quite low (< 10%) with both routes of administration. High tissue concentrations and high tissue:plasma concentration ratios were demonstrated for enrofloxacin and ciprofloxacin 24 h after treatment. It was concluded that a dose of 10 mg/kg per day provides serum and tissue concentrations sufficiently high to be effective in the control of many infectious diseases of ducks.

PMID:
9061885
[PubMed - indexed for MEDLINE]
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