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J Rheumatol. 1997 Mar;24(3):576-8.

Antinuclear antibody positivity in pediatric patients with autoimmune thyroid disease.

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  • 1Department of General Pediatrics, Nerima Hikarigaoka Hospital, Nihon University School of Medicine, Tokyo, Japan.

Abstract

OBJECTIVE:

The incidence of antinuclear antibody (ANA) positivity was investigated in pediatric patients with autoimmune thyroid diseases.

METHODS:

Subjects were 21 untreated patients with Graves' disease, 12 untreated patients with Hashimoto's disease, and 16 untreated patients with non-autoimmune thyroid disease, including one patient with Plummer's disease, 11 patients with simple goiter (probable), and 4 patients with cretinism. Patients with Graves' disease were treated with either propylthiouracil or methimazole. ANA was measured using HEp-2 cells. Anti-dsDNA antibody was measured using double stranded DNA derived from an Escherichia coli plasmid.

RESULTS:

The incidence of ANA positivity was significantly higher in patients with untreated Graves' disease (n = 21; age range 9-15 yrs) than in Hashimoto's thyroiditis (n = 12; age range 7-15 yrs) (p < 0.03, Fisher's exact probability test). However, the 2 diseases were not significantly different with respect to anti-dsDNA antibody positivity. Most of the ANA positive patients with Graves' disease required treatment for more than 2 years, unlike the 6 ANA negative patients (p < 0.002, Fisher's exact probability test).

CONCLUSION:

We conclude that ANA positivity may predict a poor response to antithyroid drugs in Graves' disease.

PMID:
9058668
[PubMed - indexed for MEDLINE]
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