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    Annu Rev Neurosci. 1997;20:483-532.

    PAX-6 in development and evolution.

    Callaerts P, Halder G, Gehring WJ.

    Department of Cell Biology, Biozentrum, University of Basel, Switzerland.

    Pax-6 is a member of the Pax gene class and encodes a protein containing a paired domain and a homeodomain. The molecular characterization of Pax-6 genes from species of different animal phyla and the analysis of Pax-6 function in the developing eyes and central nervous system of vertebrates, Drosophila melanogaster, and Caenorhabditis elegans suggest that Pax-6 homologues share conserved functions. In this review, we present recent data on the structural and functional characterization of Pax-6 homologues from species of different animal phyla. We discuss the implications of these findings for our understanding of the development and evolution of eyes and nervous systems.

    PMID: 9056723 [PubMed - indexed for MEDLINE]

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