Carbon monoxide poisoning as an epigenetic factor ...[Korean J Ophthalmol. 1996]

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1: Korean J Ophthalmol. 1996 Dec;10(2):122-3. Links

Carbon monoxide poisoning as an epigenetic factor for Leber's hereditary optic neuropathy.

Hwang JM, Park HW.

Department of Ophthalmology, Seoul City Boramae Hospital, Korea.

A 45-year-old Korean woman visited our hospital complaining of poor vision after carbon monoxide (CO) poisoning. We have confirmed the presence of a point mutation at position 11778 in the ND4 gene of mitochondrial DNA. This case suggests that CO poisoning may precipitate the clinical expression of Leber's hereditary optic neuropathy (LHON). To our knowledge, this would be the first case report of clinical expression of LHON precipitated by CO poisoning.

PMID: 9055542 [PubMed - indexed for MEDLINE]

A family with Leber's hereditary optic neuropathy with mitochondrial 11778/ND4 and 4216/ND1 mutations. [Korean J Ophthalmol. 2000]
Leber's hereditary optic neuropathy. Clinical manifestations of the 15257 mutation. [Ophthalmology. 1993]
High frequency of mutations at position 11778 in mitochondrial ND4 gene in Japanese families with Leber's hereditary optic neuropathy. [Hum Genet. 1993]
The mitochondrial ND6 gene is a hot spot for mutations that cause Leber's hereditary optic neuropathy. [Brain. 2001]
Leber's hereditary optic neuropathy: clinical and molecular genetic results obtained in a family with a new point mutation at nucleotide position 14498 in the ND 6 gene. [Ger J Ophthalmol. 1996]
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Carbon monoxide poisoning as an epigenetic factor for Leber's hereditary optic neuropathy.

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