Isolation of two flavonoids from Tanacetum microphyllum as PMA-induced ear edema inhibitors

J Martinez; A M Silván; M J Abad; P Bermejo; A Villar; M Söllhuber

doi:10.1021/np960163u

Isolation of two flavonoids from Tanacetum microphyllum as PMA-induced ear edema inhibitors

J Nat Prod. 1997 Feb;60(2):142-4. doi: 10.1021/np960163u.

Authors

J Martinez¹, A M Silván, M J Abad, P Bermejo, A Villar, M Söllhuber

Affiliation

¹ Department of Pharmacology, Faculty of Pharmacy, University Complutense, Madrid, Spain.

PMID: 9051913
DOI: 10.1021/np960163u

Abstract

The CH2Cl2 extract of Tanacetum microphyllum exhibited antiinflammatory activity on PMA-mouse ear model. Two antiinflammatory flavonoids, 5,7-dihydroxy-3,6,4'-trimethoxyflavone (santin) (1) and 5,7-dihydroxy-3,4'-dimethoxyflavone (ermanin) (2), were isolated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Ear / pathology
Edema / chemically induced
Edema / prevention & control*
Female
Flavonoids / chemistry
Flavonoids / isolation & purification*
Flavonoids / pharmacology
Mice
Plants / chemistry*
Spectrophotometry, Ultraviolet
Tetradecanoylphorbol Acetate / toxicity*

Substances

Flavonoids
ermanin
santin
Tetradecanoylphorbol Acetate