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Trends Biochem Sci. 1997 Feb;22(2):63-7.

The ER-overload response: activation of NF-kappa B.

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  • 1Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany.


Various conditions that perturb the function of the endoplasmic reticulum (ER) were recently shown to activate the transcription factor NF-kappa B. Activation of NF-kappa B is caused by the accumulation of proteins in the ER membrane, a condition we have called ER overload. Both the release of Ca2+ from the ER and the subsequent production of reactive oxygen intermediates are required for ER-overload-mediated NF-kappa B activation. This novel intracellular signal transduction pathway might be important in antiviral defense and play a role in various diseases as well as in B-cell development.

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