Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Biochem Sci. 1997 Feb;22(2):63-7.

The ER-overload response: activation of NF-kappa B.

Author information

  • 1Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany. pahl@sun2.ruf.uni-freiburg.de

Abstract

Various conditions that perturb the function of the endoplasmic reticulum (ER) were recently shown to activate the transcription factor NF-kappa B. Activation of NF-kappa B is caused by the accumulation of proteins in the ER membrane, a condition we have called ER overload. Both the release of Ca2+ from the ER and the subsequent production of reactive oxygen intermediates are required for ER-overload-mediated NF-kappa B activation. This novel intracellular signal transduction pathway might be important in antiviral defense and play a role in various diseases as well as in B-cell development.

PMID:
9048485
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk