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J Cardiovasc Risk. 1996 Oct;3(5):427-33.

Association of body mass index, blood pressure and serum levels of triglycerides and high-density lipoprotein cholesterol in childhood with the insulin sensitivity index in young adulthood: a 13-year follow-up.

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  • 1Medical Department C, Glostrup Hospital, University of Copenhagen, Denmark.

Abstract

BACKGROUND:

Tracking of body mass index (BMI), blood pressure and serum lipids from childhood to adulthood has been demonstrated in previous studies. Whether these factors are associated with the insulin-sensitivity index measured in young adulthood (ISIadult) remains undetermined.

OBJECTIVES:

To determine whether any association exists between the ISIadult and BMI, blood pressure and plasma lipids measured in childhood (1979).

METHODS:

The study included 227 unrelated white subjects (aged 18-32 years). Their ISIadult were measured in 1992/93 with a combined intravenous glucose (0.3 gl/kg body weight) and tolbutamide (3 mg/kg body weight) tolerance test. BMI, blood pressure and blood lipids were measured in 1979 and again in 1992/93.

RESULTS:

In men, plasma high-density lipoprotein cholesterol (HDLC) in 1979 (rs = 0.25, F = 0.006) was positively associated with ISIadult and plasma triglyceride measured in 1979 (rs = -0.34, P = 0.001). BMI (rs = -0.29, P = 0.002) and systolic blood pressure, both measured in 1979 (rs = -0.29, P = 0.002) were associated negatively with ISIadult. In women, plasma HDLC measured in 1979 was associated positively and significantly with ISIadult (rs = 0.21, P = 0.024) and BMI measured in 1979 was associated significantly and negatively with ISIadult (rs = -0.22, P = 0.018). Plasma triglyceride or systolic blood pressure, both measured in 1979, were not associated with ISIadult. In gender-stratified multiple-regression analyses [controlling for waist circumference(adult) maximal aerobic capacity (VO2max(adult)), age and women's use of oral contraceptives], plasma HDLC measured in 1979 was associated significantly with ISIadult in men (P = 0.026) but not in women (P = 0.066). A negative association was found between plasma triglyceride measured in 1979 and ISIadult (P = 0.045) in men, but not in women (P = 0.30). BMI, total cholesterol and systolic and diastolic blood pressure, all measured in 1979, were not associated with ISIadult.

CONCLUSION:

Low plasma HDLC, high plasma triglyceride and high BMI in childhood are associated with low insulin-sensitivity index values in young adulthood.

PMID:
9048257
[PubMed - indexed for MEDLINE]
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