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J Allergy Clin Immunol. 1997 Feb;99(2):204-9.

Comparative efficacy of inhaled furosemide and disodium cromoglycate in the treatment of exercise-induced asthma in children.

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  • 1Department of Pediatrics, Escola Paulista de Medicina, Federal University of São Paulo, Brasil.

Abstract

BACKGROUND:

Inhaled furosemide has been shown, in patients with asthma, to have prophylactic properties similar to those of disodium cromoglycate.

OBJECTIVE:

The aim of this study was to evaluate the protective effect of these drugs in the treatment of exercise-induced asthma.

METHODS:

Fifteen children with exercise-induced asthma (mean age, 10.8 years) underwent exercise challenge after a single dose of nebulized placebo, furosemide (20 mg/m7 body area), or disodium cromoglycate (20 mg), 2 days apart, in a single-blind crossover trial.

RESULTS:

Both furosemide and disodium cromoglycate exerted significant protection against the bronchial response to exercise challenge, with a mean maximum percentage falls in FEV1 of 4.66% and 7.22%, respectively (p < 0.05). On the placebo day, the mean maximum percentage fall in FEV1 was 34.50% (p < 0.05).

CONCLUSION:

The results of this study suggest that furosemide and disodium cromoglycate provide comparable efficacy in preventing exercise-induced asthma in children, with no side effects.

PMID:
9042046
[PubMed - indexed for MEDLINE]
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