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Can J Psychiatry. 1997 Feb;42(1):27-33.

The role of the thalamus in schizophrenia.

Author information

  • Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City 52242, USA.

Abstract

BACKGROUND:

Explaining the diversity of symptoms that occur in schizophrenia is a major conceptual challenge. Perhaps the most powerful strategy is to identify a fundamental cognitive process and/or a fundamental neural circuit.

METHODS:

Convergent data from our research group in Iowa and from investigators in other centres are summarized.

RESULTS:

The thalamus plays a key role in information processing. A defect in circuitry connecting the thalamus, frontal cortex, and cerebellum could explain a wide range of symptoms. Neuropathology and imaging studies suggest that patients with schizophrenia may have abnormalities in this circuitry.

CONCLUSION:

The fundamental deficit in schizophrenia may be conceptualized as a "cognitive dysmetria" characterized by impairments in coordinating the perception, encoding, retrieval, and prioritization of experience and information.

Comment in

PMID:
9040920
[PubMed - indexed for MEDLINE]
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