Abstract
Distribution of endothelin-1 (ET-1) in the cochlea of normal guinea pigs was determined by immunohistochemistry. ET-1 activity was identified with the mouse anti-human ET-1 IgG1 monoclonal antibody. ET-1 activity was distributed in the modiolus, spiral ligament, stria vascularis, spiral prominence. Reissner's membrane, supporting cells of the organ of Corti and spiral ganglion cells. These findings suggest that ET-1 may be involved in the regulation of fluid volume and ions of the cochlea.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal
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Cochlea / cytology
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Cochlea / immunology
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Cochlea / metabolism*
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Endothelin-1 / immunology
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Endothelin-1 / metabolism*
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Female
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Guinea Pigs
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Hair Cells, Auditory, Outer / cytology
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Hair Cells, Auditory, Outer / immunology
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Hair Cells, Auditory, Outer / metabolism
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Immunohistochemistry
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Organ of Corti / cytology
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Organ of Corti / immunology
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Organ of Corti / metabolism
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Spiral Ganglion / cytology
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Spiral Ganglion / immunology
Substances
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Antibodies, Monoclonal
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Endothelin-1