Neth J Med. 1997 Jan;50(1):21-4.

Mannitol-induced acute renal failure.

van Hengel P, Nikken JJ, de Jong GM, Hesp WL, van Bommel EF.

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Department of Internal Medicine, Drechtsteden Ziekenhuis, AK Dordrecht, Netherlands.

Abstract

Mannitol is widely used because of its osmotic diuretic action and its presumed antioxidant properties. In pre-existent renal dysfunction, however, mannitol may accumulate leading to potentially deleterious effects. We describe a 71-year-old woman with moderate chronic renal failure due to diabetic nephropathy who developed acute anuric renal failure after mannitol administration for post-traumatic reflex sympathetic dystrophy. After haemodialysis symptoms of acute renal failure rapidly disappeared with recovery of pre-existent renal function. Daily measurement of the osmolal gap as a simple and accurate way of monitoring patients receiving mannitol infusion is emphasized. A rapid increase in the osmolar gap should prompt adjustment of the dose or even discontinuation of mannitol, especially in the case of pre-existent risk factors.

PMID:: 9038039; [PubMed - indexed for MEDLINE]

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Cited by 1 PubMed Central article

A comparative study on the efficacy of 10% hypertonic saline and equal volume of 20% mannitol in the treatment of experimentally induced cerebral edema in adult rats. [BMC Neurosci. 2010]
A comparative study on the efficacy of 10% hypertonic saline and equal volume of 20% mannitol in the treatment of experimentally induced cerebral edema in adult rats.
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