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Glia. 1997 Feb;19(2):104-10.

Dying-back oligodendrogliopathy: a late sequel of myelin-associated glycoprotein deficiency.

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  • 1Institute of Neurology, University of Vienna, Austria.


Ultrastructural analysis of myelin from 8-month-old mice deficient in the myelin-associated glycoprotein revealed pronounced and characteristic alterations of the periaxonal oligodendrocyte processes, consisting of intracytoplasmic deposition of vesicular material, multivesicular bodies, mitochondria, and lipofuscin granules, as well as granular or paracrystalline inclusions. These alterations are similar to those described before as "dying-back oligodendrogliopathy" in diseases of toxic or immune-mediated demyelination including multiple sclerosis.

[PubMed - indexed for MEDLINE]
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