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Replicative senescence and cell immortality: the role of telomeres and telomerase.
Geron Corporation, Menlo Park, California 94025, USA.
Telomere shortening is correlated with cell senescence in vitro and cell aging in vivo. The telomere hypothesis suggests that telomere length serves as a mitotic clock for timing cellular replicative life span. Expression of telomerase stabilizes telomere length and allows for continual replication, or cell immortality. This article reviews recent evidences for the role of telomere length and telomerase in the regulation of cellular replicative life span. The therapeutic potential of manipulating telomerase expression and telomere length is also discussed.
PMID: 9034126 [PubMed - indexed for MEDLINE]
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Cited by 4 PubMed Central articles
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Characteristics of primary and immortalized fibroblast cells derived from the miniature and domestic pigs.
Oh HY, Jin X, Kim JG, Oh MJ, Pian X, Kim JM, Yoon MS, Son CI, Lee YS, Hong KC, et al.
BMC Cell Biol. 2007 Jun 1; 8:20. Epub 2007 Jun 1.
[BMC Cell Biol. 2007]
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Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate.
Iakova P, Wang GL, Timchenko L, Michalak M, Pereira-Smith OM, Smith JR, Timchenko NA.
EMBO J. 2004 Jan 28; 23(2):406-17. Epub 2004 Jan 15.
[EMBO J. 2004]
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Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression.
Horikawa I, Cable PL, Mazur SJ, Appella E, Afshari CA, Barrett JC.
Mol Biol Cell. 2002 Aug; 13(8):2585-97.
[Mol Biol Cell. 2002]
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