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    Genomics. 1997 Jan 15;39(2):231-4.

    The cloning of a human ABC gene (ABC3) mapping to chromosome 16p13.3.

    Connors TD, Van Raay TJ, Petry LR, Klinger KW, Landes GM, Burn TC.

    Department of Human Genetics, Genzyme Genetics, Framingham, Massachusetts 01701, USA.

    The ATP binding cassette (ABC) transporters, or traffic ATPases, constitute a large family of proteins responsible for the transport of a wide variety of substrates across cell membranes in both prokaryotic and eukaryotic cells. We describe a human ABC protein with regions of strong homology to the recently described murine ABC1 and ABC2 transporters. The gene for this novel protein, human ABC3, maps near the polycystic kidney disease type 1 (PKD1) gene on chromosome 16p13.3. The ABC3 gene is expressed at highest levels in lung compared to other tissues.

    PMID: 9027511 [PubMed - indexed for MEDLINE]

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