Five healthy volunteers were treated orally with lithium carbonate, sulphate, or chloride. There were no significant differences in area under time-concentration curves, half-lives, total body clearance or apparent distribution volumes between the various salts, either in plasma or in the RBC compartment. The carbonate salt did show a higher RBC/plasma distribution ratio than the other salts, which might possibly imply greater therapeutic effectiveness of this salt. Some considerations on the tolerability of various lithium salts are discussed.