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Aviat Space Environ Med. 1996 Sep;67(9):872-3.

Mefloquine versus doxycycline for malaria prophylaxis in intermittent exposure of Israeli Air Force aircrew in Rwanda.

Author information

  • 1Israeli Air Force Aeromedical Center, Tel Hashomer, Israel.

Abstract

BACKGROUND:

The issue of the best chemoprophylaxis agent for aircrew to use against malaria is still not settled.

METHOD:

We studied the patterns of use of both doxycycline and mefloquine in aviators and other aircrew for 2 mo during biweekly flights from Israel to Rwanda with a few hours' visits. Some 28 aviators and 15 non-aviator aircrew were treated with doxycycline and mefloquine, respectively, less than 12 h before the first flight and up to 4 wk after the last return.

RESULTS:

No case of malaria occurred within or after the operational period. Compliance was better for mefloquine than for doxycyline for the full period of the operation (100% vs. 75%, respectively). The rate of side effects, mostly gastrointestinal, was higher for doxycycline (39% vs. 13%, respectively) and was related mainly to the frequency of administration (daily vs. weekly).

CONCLUSION:

In situations involving frequent intermittent short-term visits to areas with substantial risk of acquiring malaria, we conclude that aircrew can safely take weekly mefloquine as prophylaxis.

PMID:
9025805
[PubMed - indexed for MEDLINE]
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