Trends Biochem Sci. 1997 Jan;22(1):28-31.

Catalytic hydroxyl/amine dyads within serine proteases.

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Department of Chemistry, Ohio State University, Columbus 43210, USA.

Abstract

The 'catalytic triad' mechanism, which involves a serine, histidine and aspartic acid, has become synonymous with serine proteases. However, recently, mechanistically novel serine proteases have been discovered. These proteases use hydroxyl/epsilon-amine or hydroxyl/alpha-amine 'catalytic dyads' as their reactive centers.

PMID:: 9020589; [PubMed - indexed for MEDLINE]

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