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Biol Pharm Bull. 1997 Jan;20(1):107-9.

Phenylmercury transport mediated by merT-merP genes of Pseudomonas K-62 plasmid pMR26.

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  • 1Faculty of Pharmaceutical Sciences, Setsunan University, Nagaotogecho, Hirakata, Osaka, Japan.


The merB-merA-deleted plasmid pMRD141 which contains the intact merT-merP genes of pMRA17 conferred bacterial hypersensitivity not only to Hg2+ but also to C6H5Hg+. The bacterium with pMRD141 took up significantly more C6H5Hg+ than its isogenic strain with the cloning vector Bluescript II. The hypersensitivity to C6H5Hg+ seems to be based on hyperaccumulation of toxic C6H5Hg+ in the absence of detoxifying enzymes encoded by merB and merA. Our results show that bacterial transport of C6H5Hg+ into the cytoplasm is regulated by merT-merP genes.

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