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1: Gen Pharmacol. 1997 Feb;28(2):311-5.Click here to read Links

Effect of TYB-2285 on passive cutaneous anaphylaxis in rats.

Watanabe A, Tominaga T, Shutoh H, Hayashi H, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H.

Department of Pharmacology, Toyobo Co. Ltd., Shiga, Japan.

1. TYB-2285 (1-30 mg/kg p.o.) inhibited ovalbumin (OA)- and dinitrophenyl-Ascaris (DNPAs)-induced passive cutaneous anaphylaxis (PCA) in a dose-dependent manner. 2. The ED50 of TYB-2285 and ketotifen fumarate on OA-induced PCA were 0.5 and 3.9 mg/kg, respectively. The ED50 of TYP-2285 and amlexanox on DNP-As-induced PCA were 3.5 and 0.9 mg/ kg, respectively. 3. TYB-2285 (3-30 mg/kg p.o.) inhibited histamine consumption at the PCA site. 4. Unlike cyproheptadine or amlexanox, TYB-2285 (30 mg/kg p.o.) did not inhibit histamine-, serotonin-, ascites-, 48/80-, or A23187-induced capillary permeability. It inhibited dextran-induced capillary permeability slightly. 5. These results demonstrate that TYB-2285 inhibits PCA by inhibiting histamine release, although it does not inhibit capillary permeability.

PMID: 9013210 [PubMed - indexed for MEDLINE]

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