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Antisense Nucleic Acid Drug Dev. 1996 Winter;6(4):267-72.

Resistance of morpholino phosphorodiamidate oligomers to enzymatic degradation.

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  • 1ANTIVIRALS, Inc., Corvallis, OR 97333, USA.


Oligomers possessing the Morpholino phosphorodiamidate backbone were evaluated for resistance to a variety of enzymes and biologic fluids. A 25-mer was incubated with nucleases, proteases, esterases, and serum, and the reaction mixtures were directly analyzed by MALDI-TOF mass spectrometry. The 25-mer was completely resistant to 13 different hydrolases and serum and plasma. The excellent resistance of Morpholino phosphorodiamidates to enzymatic attack indicates their suitability for in vivo use.

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