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p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells.
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Characteristic of chronic myelogenous leukemia (CML) is the presence of the chimeric p210(bcr-abl) protein possessing elevated protein tyrosine kinase activity relative to normal c-abl tyrosine kinase. Hematopoietic progenitors isolated from CML patients in the chronic phase contain a constitutively tyrosine-phosphorylated protein that migrates at 62 kDa by SDS-PAGE and associates with the p120 ras GTPase-activating protein (GAP). We have purified p62(dok) from a hematopoietic cell line expressing p210(bcr-abl). p62(dok) is a novel protein with features of a signaling molecule. Association of p62(dok) with GAP correlates with its tyrosine phosphorylation. p62(dok) is rapidly tyrosine-phosphorylated upon activation of the c-Kit receptor, implicating it as a component of a signal transduction pathway downstream of receptor tyrosine kinases.
PMID: 9008160 [PubMed - indexed for MEDLINE]
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Cited by 59 PubMed Central articles
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T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2.
Dong S, Corre B, Foulon E, Dufour E, Veillette A, Acuto O, Michel F.
J Exp Med. 2006 Oct 30; 203(11):2509-18. Epub 2006 Oct 16.
[J Exp Med. 2006]
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A nuclear export signal and phosphorylation regulate Dok1 subcellular localization and functions.
Niu Y, Roy F, Saltel F, Andrieu-Soler C, Dong W, Chantegrel AL, Accardi R, Thépot A, Foiselle N, Tommasino M, et al.
Mol Cell Biol. 2006 Jun; 26(11):4288-301.
[Mol Cell Biol. 2006]
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Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis.
Zhao M, Janas JA, Niki M, Pandolfi PP, Van Aelst L.
Mol Cell Biol. 2006 Apr; 26(7):2479-89.
[Mol Cell Biol. 2006]
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