AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):173-8.

trans-Activation of the HIV type 1 promoter by 7,8-dihydroneopterin in vitro.

Baier-Bitterlich G, Fuchs D, Zangerle R, Baeuerle PA, Werner ER, Fresser F, Uberall F, Baier G, Wachter H.

Source

Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Austria.

Abstract

Infection with human immunodeficiency virus type 1 and 2 is associated with elevated concentrations of neopterin, released in large quantities by human macrophages on stimulation with interferon gamma. Evidence has suggested a potential role of neopterin derivatives in oxygen radical-mediated processes. Here we show that the redox-sensitive transcription factors AP-1 and NF-kappaB are activated by 7,8-dihydroneopterin, either directly (AP-1), or by the synergistic action with tumor necrosis factor alpha (NF-kappaB). We could further demonstrate that 7,8-dihydroneopterin enhances HIV-1 expression as shown in transient transfection assays using HIV-1 CAT promoter-reporter gene constructs. In sera of HIV+ patients 7,8-dihydroneopterin significantly correlated with neopterin and HIV-1 p24 antigen. On the basis of our data we therefore assume that 7,8-dihydroneopterin might augment progression to higher stages of HIV-associated disease.

PMID:: 9007202; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Review Role of neopterin and 7,8-dihydroneopterin in human immunodeficiency virus infection: marker for disease progression and pathogenic link. [J Acquir Immune Defic Syndr Hu...]
Review Role of neopterin and 7,8-dihydroneopterin in human immunodeficiency virus infection: marker for disease progression and pathogenic link.
Baier-Bitterlich G, Wachter H, Fuchs D. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Oct 1; 13(2):184-93.
The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites. [J Virol. 2000]
The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites.
Lim SP, Garzino-Demo A. J Virol. 2000 Feb; 74(4):1632-40.
ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB. [J Biol Chem. 1999]
ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB.
Yang X, Chen Y, Gabuzda D. J Biol Chem. 1999 Sep 24; 274(39):27981-8.
Lack of responsiveness of a nuclear factor-kappaB-regulated promoter to transactivation by human immunodeficiency virus 1 Tat in HeLa cells. [Virology. 1999]
Lack of responsiveness of a nuclear factor-kappaB-regulated promoter to transactivation by human immunodeficiency virus 1 Tat in HeLa cells.
Kelly GD, Morris CB, Offermann MK. Virology. 1999 Oct 10; 263(1):128-38.
Review Chronic immune stimulation, oxidative stress, and apoptosis in HIV infection. [Biochem Pharmacol. 1997]
Review Chronic immune stimulation, oxidative stress, and apoptosis in HIV infection.
Baier-Bitterlich G, Fuchs D, Wachter H. Biochem Pharmacol. 1997 Mar 21; 53(6):755-63.

See reviews... See all...

Cited by 1 PubMed Central article

Neopterin-induced expression of intercellular adhesion molecule-1 (ICAM-1) in type II-like alveolar epithelial cells. [Clin Exp Immunol. 1999]
Neopterin-induced expression of intercellular adhesion molecule-1 (ICAM-1) in type II-like alveolar epithelial cells.
Hoffmann G, Rieder J, Smolny M, Seibel M, Wirleitner B, Fuchs D, Schobersberger W. Clin Exp Immunol. 1999 Dec; 118(3):435-40.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

trans-Activation of the HIV type 1 promoter by 7,8-dihydroneopterin in vitro.
trans-Activation of the HIV type 1 promoter by 7,8-dihydroneopterin in vitro.
AIDS Res Hum Retroviruses. 1997 Jan 20 ;13(2):173-8.

PubMed
Wild-type strains of Dictyostelium discoideum can be transformed using a novel s...
Wild-type strains of Dictyostelium discoideum can be transformed using a novel selection cassette driven by the promoter of the ribosomal V18 gene.
Plasmid. 1996 Nov ;36(3):169-81.

PubMed
Functional analysis of surfactant protein B (SP-B) promoter. Sp1, Sp3, TTF-1, an...
Functional analysis of surfactant protein B (SP-B) promoter. Sp1, Sp3, TTF-1, and HNF-3alpha transcription factors are necessary for lung cell-specific activation of SP-B gene transcription.
J Biol Chem. 1997 Jan 31 ;272(5):3083-90.

PubMed
Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activ...
Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells.
J Biol Chem. 1997 Jan 31 ;272(5):2620-8.

PubMed
Are short normal children at a disadvantage? The Wessex growth study.
Are short normal children at a disadvantage? The Wessex growth study.
BMJ. 1997 Jan 11 ;314(7074):97-100.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

trans-Activation of the HIV type 1 promoter by 7,8-dihydroneopterin in vitro.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information