Abstract
The paper reports the structures, syntheses and pharmacological properties of new compounds having a 2-aminobenzimidazole group. They exhibit various activities: histamine H1- and H2-receptors blocking activities, antilipidemic and platelet antiaggregatory, anti-inflammatory and analgesic properties, antimicrobial, fungicidal, parasiticide, antiarrythmic activity and muscle relaxant, comparable to those of drugs used in therapy.
MeSH terms
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Anthelmintics / chemical synthesis
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Anthelmintics / pharmacology
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Anti-Arrhythmia Agents / chemical synthesis
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Anti-Arrhythmia Agents / pharmacology
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / pharmacology
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Histamine H1 Antagonists / chemical synthesis
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Histamine H1 Antagonists / pharmacology
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Histamine H2 Antagonists / chemical synthesis
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Histamine H2 Antagonists / pharmacology
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Hypolipidemic Agents / chemical synthesis
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Hypolipidemic Agents / pharmacology
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Muscle Relaxants, Central / chemical synthesis
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Muscle Relaxants, Central / pharmacology
Substances
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Anthelmintics
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Anti-Arrhythmia Agents
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Anti-Infective Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Benzimidazoles
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Histamine H1 Antagonists
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Histamine H2 Antagonists
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Hypolipidemic Agents
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Muscle Relaxants, Central