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Life Sci. 1995 Feb 17;56(13):1121-6.

CYP2E1 genotypes and serum LAP in Japanese alcoholics.

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  • 1Department of Neuropsychiatry, Kagawa Medical School, Kita-gun, Japan.


The genotypes of the ALDH2 and CYP2E1 loci of Japanese alcoholic patients were determined to investigate the susceptibility to alcoholic liver injury. In alcoholics with a liver-function disorder, a significant association was observed between the genotypes of the CYP2E1 loci and the serum level of a liver-derived enzyme, LAP. However, there was no significant association between the ALDH2 genotypes and liver dysfunction.

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