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    Science. 1997 Jan 24;275(5299):540-3.

    Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function.

    Mittrücker HW, Matsuyama T, Grossman A, Kündig TM, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi PS, Mak TW.

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    Department of Immunology, University of Toronto, Toronto, Ontario, M5G 2C1, Canada.

    Abstract

    Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.

    PMID:
    8999800
    [PubMed - indexed for MEDLINE]

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