Curr Opin Immunol. 1996 Dec;8(6):837-42.

Manipulation of the Th1/Th2 balance in autoimmune disease.

Source

Center For Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA.

Abstract

Many autoimmune diseases are caused by autopathogenic Th1 cells. Because in vitro Th1 and Th2 cells cross-regulate each other, it is likely that the induction of self-antigen-specific Th2 cells can prevent autoimmune disease. In the past year, investigators have further defined the role of Th1 and Th2 cytokines in the induction and regulation of autoimmunity. Furthermore, the role of MHC-antigen-T-cell avidity (strength of signal) in inducing such protective immune responses has been elucidated.

PMID:: 8994864; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Review The Th1/Th2 balance in autoimmunity. [Curr Opin Immunol. 1995]
Review The Th1/Th2 balance in autoimmunity.
Charlton B, Lafferty KJ. Curr Opin Immunol. 1995 Dec; 7(6):793-8.
Review Differential involvement of Th1 and Th2 cytokines in autoimmune diseases. [Autoimmunity. 1996]
Review Differential involvement of Th1 and Th2 cytokines in autoimmune diseases.
Kroemer G, Hirsch F, González-García A, Martínez C. Autoimmunity. 1996; 24(1):25-33.
Review Manipulation of the Th1/Th2 cell balance: an approach to treat human autoimmune diseases? [Autoimmunity. 1996]
Review Manipulation of the Th1/Th2 cell balance: an approach to treat human autoimmune diseases?
Adorini L, Guéry JC, Trembleau S. Autoimmunity. 1996; 23(1):53-68.
Review T-cell regulation in murine and human autoimmune diabetes: the role of TH1 and TH2 cells. [Diabetes Metab. 1997]
Review T-cell regulation in murine and human autoimmune diabetes: the role of TH1 and TH2 cells.
Heurtier AH, Boitard C. Diabetes Metab. 1997 Nov; 23(5):377-85.
Review The role of helper T cell subsets in autoimmune diseases. [Cytokine Growth Factor Rev. 1998]
Review The role of helper T cell subsets in autoimmune diseases.
Lafaille JJ. Cytokine Growth Factor Rev. 1998 Jun; 9(2):139-51.

See reviews... See all...

Cited by 26 PubMed Central articles

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. [Proc Natl Acad Sci U S A. 2012]
Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors.
Bandukwala HS, Gagnon J, Togher S, Greenbaum JA, Lamperti ED, Parr NJ, Molesworth AM, Smithers N, Lee K, Witherington J, et al. Proc Natl Acad Sci U S A. 2012 Sep 4; 109(36):14532-7. Epub 2012 Aug 21.
Down-regulated NOD2 by immunosuppressants in peripheral blood cells in patients with SLE reduces the muramyl dipeptide-induced IL-10 production. [PLoS One. 2011]
Down-regulated NOD2 by immunosuppressants in peripheral blood cells in patients with SLE reduces the muramyl dipeptide-induced IL-10 production.
Yu SL, Wong CK, Wong PT, Chen DP, Szeto CC, Li EK, Tam LS. PLoS One. 2011; 6(8):e23855. Epub 2011 Aug 19.
A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans. [PLoS One. 2011]
A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.
Marsh EK, van den Berg MC, May RC. PLoS One. 2011 Mar 2; 6(3):e16839. Epub 2011 Mar 2.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Manipulation of the Th1/Th2 balance in autoimmune disease.
Manipulation of the Th1/Th2 balance in autoimmune disease.
Curr Opin Immunol. 1996 Dec ;8(6):837-42.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: