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Curr Opin Genet Dev. 1996 Dec;6(6):715-22.

Gen(om)e duplications in the evolution of early vertebrates.

Author information

  • Whitehead Institute, Cambridge, Massachusetts 02142, USA. arend@genome.wi.mit.edu

Abstract

Phylogenetic analyses and sequence surveys of developmental regulator gene families indicate that two large-scale gene duplications, most likely genome duplications, occurred in ancestors of vertebrates. Relaxed constraints allowed duplicated and thus redundant genes to diverge in a two stage mechanism. Neutral changes dominated at first but then positively selected regulatory changes evolved the novel and increasingly complex vertebrate developmental program.

PMID:
8994842
[PubMed - indexed for MEDLINE]
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